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Folic acid is readily and completely absorbed in the gastro-intestinal tract, preferably in the upper 12-duodenum.
Intensively bound to plasma proteins. It penetrates through the blood-brain barrier, the placenta and breast milk. Time to maximum concentration -60 minutes.
Deposited and metabolized in the liver to form tetrahydrofolic acid (in the presence of ascorbic acid by the action of dihydrofolate reductase). Predominantly trenbolone excreted by the kidneys as metabolites; if the received dose is much higher than the daily requirement of folic acid, it appears unchanged.

Indications

  • treatment of folate deficiency, including background unbalanced and malnutrition;
  • prevention of neural tube defects in the fetus in the I trimester of pregnancy;
  • treatment and prevention of anemia, against folic acid deficiency: macrocytic hyperchromic anemia, anemia and leucopenia caused by drugs and ionizing radiation, megablastnoy anemia, post-resection of anemia, anemia associated with small bowel disease, sprue, and malabsorption syndrome.

Contraindications
: Hypersensitivity to the drug, pernicious anemia, cancer, cobalamin deficiency.

Dosage and administration:
Apply orally after meal.
To prevent the development of the fetus neural tube defects in the I trimester of pregnancy – 1 mg per day.
With the purpose of treatment: adults 1-2 mg per day. Depending on the state the dose may be increased up to 5 mg per day.

Side effects:
Allergic reactions (skin rash, pruritus, erythema, bronchospasm, pyrexia); on the part of the gastrointestinal tract: anorexia, nausea, abdominal distention, bitter taste in the mouth.
With prolonged use may develop hypovitaminosis trenbolone.

Interaction with other drugs
reduces the effect of phenytoin (requires an increase in the dose).
Analgesics (long-term therapy), anticonvulsants (including phenytoin and carbamazepine), estrogens, oral contraceptives increase the need for folic acid.
Antacids (including drugs calcium, aluminum and magnesium), cholestyramine, sulfonamino (including sulfasalazine) reduce folic acid absorption.
Methotrexate, pyrimethamine, triamterene, trimethoprim inhibit dihydrofolate reductase and reduce the folic acid effect (instead of patients treated with these drugs should be prescribed calcium folinate).
When an application with chloramphenicol, neomycin, polymyxin, tetracycline, folic acid intake is reduced.

Special instructions
for the prevention of folic acid, vitamin deficiencies, most preferably a balanced diet. Foods rich trenbolone in folic acid -. Lettuce, spinach, tomatoes, carrots, fresh liver, beans, beets, eggs, cheese, nuts, cereals
Folic acid was not used for the treatment  deficiency (pernicious anemia), normocytic and aplastic anemia, as well as anemia, refractory to therapy. In pernicious , folic acid, improves hematologic parameters, masks neurological complications. It is not ruled out pernicious anemia, folic acid appointment at doses exceeding 0.4 mg / day are not recommended (isklyuchenie- during pregnancy and lactation). Patients on dialysis need high amounts of folic acid.
During treatment with antacids should be applied after 2 hours after administration of folic acid, cholestyramine -. For trenbolone before or 1 hour after folic acid
Antibiotics may distort (knowingly give too low values) of microbiological evaluation of plasma concentrations of folic acid and red blood cells.
When large doses of folic acid, as well as therapy for a long period is possible to reduce the concentration of vitamin B12.