Adverse reactions that were recorded when applying isoflurane usually dose dependent and reflect the pharmacological activity of the drug.
These include suppression of respiratory functions, arterial gipotenziiyu and arrhythmias.
In the postoperative period were observed chills, nausea, vomiting, and bowel obstruction.
As with the use of other means for inhalation general anesthesia, noted transient increase in the number of white blood cells, even in the absence of trenbolone acetate surgical stress.
Isoflurane increases the effects of muscle relaxants, especially non-depolarizing. Adults is reduced with simultaneous inhalation of nitric oxide.
In very rare cases, isoflurane induced liver injury (from a small and transient increase in liver enzymes to gepatsitov necrosis).
If overdose is necessary to stop the introduction of isoflurane to maintain airway patency, to start supporting or controlled ventilation with the introduction of oxygen and maintain adequate function of the cardiovascular system.
SPECIAL INSTRUCTIONS General Since using isoflurane anesthesia level can quickly and easily be changed, it is recommended to use only carefully calibrated vaporizers or monitoring, allowing to estimate the concentration of inhaled and exhaled. The degree of hypotension and respiratory depression may be some indication of the depth of anesthesia. Clinical experience of using isoflurane, even during long-term exposure does not give information about hepatotoxicity. However, the lack of extensive experience re-use of isoflurane, not to determine the effects of such exposure on liver function. As with other halogenated agents, isoflurane must be used with caution in patients with increased intracranial pressure. In these cases it may be required controlled hyperventilation.
Laboratory findings were observed transient changes in bromsulftaleinovogo test, increased blood glucose and serum creatinine and decreased residual urea nitrogen, serum cholesterol and alkaline phosphatase. The use of cesarean section Isoflurane at concentrations up to 0.75% for the demonstrated safety the effective maintenance of anesthesia for caesarean section. Adverse reactions to the use of isoflurane for cesarean section was observed. Children under 2 years of age Isoflurane trenbolone acetate may be used in infants and children up to 2 years is acceptable to all other commonly used tools for anesthesia degree of benefit and risk.
Malignant hyperthermia in susceptible individuals powerful inhalation anesthetic isoflurane including, hypermetabolic state may cause skeletal muscle, leading to increased oxygen demand of the development and the clinical syndrome known as malignant hyperthermia. The first sign of this syndrome is hypercapnia, and its clinical symptoms may include muscle rigidity, tachycardia, tachypnea, cyanosis, arrhythmias, and / or unstable blood pressure. Some of these nonspecific signs may also appear during light anesthesia, acute hypoxia, hypercapnia, and hypovolemia. Treatment of malignant hyperthermia involves the abolition of the drugs that caused its development, intravenous dantrolene and supportive symptomatic therapy. Later trenbolone acetate it may develop renal failure, and therefore should be controlled as much as possible to maintain diuresis. The use of inhalation anesthesia in children rarely caused increase in serum potassium levels, leading to the development of cardiac arrhythmias and death in the postoperative period. This condition can occur especially in patients with latent or explicitly occurring neurological diseases, especially in patients with Duchenne muscular dystrophy. In some cases, there was a connection with the simultaneous use of succinylcholine. These patients also experienced a significant increase in serum creatine kinase levels, changes in the composition of urine and myoglobinuria.In contrast to malignant hyperthermia and in the manifestation of a certain similarity in these patients never marked muscle rigidity or symptoms associated with muscle hypermetabolism. With the threat of such states, especially to patients with current latent neuromuscular disease, should immediately initiate action to relief of hyperkalemia and resistant arrhythmias.