Depending on the clinical efficacy of the drug dose may be increased . The duration of treatment depends on the clinical effectiveness. In oropharyngeal candidiasis, including patients with impaired immunity, the usual dose is 50-100mg once daily for 7-14 days. If necessary, treatment can be prolonged, especially in severe violations of the immune system. In other Candida infections, such as esophagitis, non-invasive bronchopulmonary infections, candiduria, candidiasis of the skin and mucous membranes, the usual daily dose is 50-100 mg for 14-30 days. for the prevention of fungal infections in patients with malignancy dose fluconazole should be 50 mg once a day for as long as the patient is at high risk due to cytostatic therapy or radiotherapy. Pediatric Use As tren side effects with similar infections in adults, duration of treatment It depends on the clinical and mycological effect. In children, the drug should not be applied in a daily dose greater than that of adults.
Fluconazole is used on a daily basis once a day. For the treatment of generalized candidiasis and cryptococcal infection recommended dose is 6-12 mg / kg / day depending on the severity of the disease. For the prevention of fungal infections in patients immunocompromised drug prescribed by 3-12mg / kg / day. In newborns fluconazole appears slower, so the first 2 weeks of life of the drug is administered in the same dose (in mg / kg), and that more children older, but at intervals of 72 hours. Children aged 3 and 4 weeks of life, the same dose is administered every 48 hours. Use in the elderly In the absence of impaired renal function should follow the usual recommendations for dosage of the drug. For patients with impaired renal function , the dosing regimen should be adjusted as indicated below. Use in patients with renal impairment Fluconazole is excreted mainly in the urine in unchanged form.In single dose changes in dose are required.In patients (including children) with impaired renal function when re-taking the drug should initially enter a “shock” dose of 50 mg to 400 mg.
headache, dizziness, change in taste, nausea, vomiting, diarrhea, flatulence, abdominal pain, abnormal liver function (jaundice, elevated alkaline phosphatase and transaminases, hyperbilirubinemia, hepatocellular necrosis), including: fatal, kidney failure, seizures, neutropenia, agranulocytosis, prolongation of the interval , flickering / ventricular flutter, hypercholesterolemia, hypertriglyceridemia, hypokalemia, alopecia, Stevens-Johnson syndrome, toxic epidermal necrolysis, leukopenia, thrombocytopenia, skin rash, anaphylactoid reaction.
Overdose Symptoms: . Hallucinations, paranoid behavior With tren side effects an overdose of the drug can be quite symptomatic treatment (with supportive activities and gastric lavage if necessary). Fluconazole appears mainly in the urine; forced diuresis can probably speed up the excretion of the drug. After a three-hour hemodialysis fluconazole plasma concentration decreases by about 50%.
Interaction with other drugs anticoagulants in patients receiving fluconazole tren side effects and coumarin anticoagulants requires careful monitoring of the prothrombin time, as it may be extended. Sulfonylureas:Fluconazole, while admission, may extend the half-life of oral drugs sulfonylureas, therefore should be in their joint application . consider the possibility of hypoglycemia phenytoin: simultaneous administration of fluconazole and phenytoin may cause a higher concentration of phenytoin to a clinically significant degree, which requires a reduction of the dose. rifampicin: while taking rifampicin and fluconazole reduced the maximum concentration and half-life of the latter, therefore; if necessary combined use should increase the dose of fluconazole. Rifabutin: co-administration of fluconazole and rifabutin is accompanied by increased serum levels of the latter, may develop uveitis. Tacrolimus: in the combined use of fluconazole and cyclosporine is recommended to monitor the concentration of the latter in the blood, because it may increase. terfenadine and astemizole : taking into account the emergence of serious, life-threatening arrhythmias in patients receiving azole antifungals in conjunction with terfenadine or astemizole, their co-administration is contraindicated.